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MICHIGAN STATE UNIVERSITY
College of Natural Science
Parent Lab

Publications

Kristin N. Parent

  1. Subramanian S, Bergland Drarvik SM, Tinney KR, Doore SM, Parent KN (2024) Moo19 and B2: Structures of Schitoviridae podophages with T=9 geometry and tailspikes with esterase activity. Science Advances, 18 December 2024. [PDF]
  2. Cortines JR, Bridges CM, Subramanian S, Schrad JR, Araujo GRS, Nunes GHP, Oliveira JdS, Essus VA, Abrahao JS, White S, Parent KN, Teschke C (2024) Transition metals and oxidation reactions trigger stargate opening during the initial stages of the replicative cycle of the giant Tupanvirus. mBio. [PDF]
  3. Subramanian S, Bergland Drarvik SM, Tinney KR, Parent KN (2024) Cryo-EM structure of a Shigella podophage reveals a hybrid tail and novel decoration proteins. Structure 32:24-34. [PDF]
  4. Parent KN (2023). The phage fought the cells, and the phage won: a satellite symposium at the ASV 2023 annual meeting. Journal of Virology. [PDF]
  5. Bittle C, Brittain K, Doore SM, Dover JA, Bergland Drarvik SM, Parent KN, Ratnayake R, Stone P, Schrad JR, Schrad K, Subramanian S, Tinney KR (2023) Phage Hunting in the High School Classroom: Phage Isolation and Characterization. The American Biology Teacher Vol 85, No 8, pp. 440-447. [PDF]
  6. Underwood SM, Roche Allred Z, Kararo AT, Parent KN, Matz RL (2022) Lessons Learned from Interdisciplinary Activities that Connect Chemistry and Biology. Scientia Global [PDF].
  7. Subramanian S, Dover JA, Parent KN, Doore SM (2022) Host Range Expansion of Shigella Phage Sf6 Evolves through Point Mutations in the Tailspike. J Virology. [PDF]
  8. Tinney KR, Dover JA, Doore SM, Parent KN (2022) Shigella viruses Sf22 and KRT47 require outer membrane protein C. BBA Biomembranes 1864. [PDF]
  9. Oliveira JdS, Lavell, AA, Essus VA, Souza G, Nunes GHP, Benicio E, Guimaraes AJ, Parent KN, Cortines JR (2021) Structure and Physiology of giant DNA viruses. Current Opinion in Virology 49:58-67. [PDF]
  10. Doore SM, Subramanian S, Tefft NM, Morona R, TerAvest MA, Parent KN (2021) Large metabolic rewiring from small genomic changes between strains of Shigella flexneri. J Bacteriol. [PDF]
  11. Roche Allred ZD, Farias AJ, Kararo AT, Parent KN, Matz RL, Underwood SM (2021) Students' use of chemistry core ideas to explain the structure and stability of DNA. Biochem. Mol. Biol. Educ. 49:55-68 [PDF]
  12. Subramanian S, Parent KN, Doore SM (2020) Ecology, Structure, and Evolution of Shigella Phages. Annu. Rev. Virol. 7:8.1-8.21 [PDF]
  13. Schrad JR, Abrahao JS, Cortines JR, Parent KN. (2020) Structural and Proteomic Characterization of the Initiation of Giant Virus Infection. Cell 181, 1-16. [PDF]
  14. Doore SM, Schrad JR, Perrett HR, Schrad KP, Dean WF, Parent KN. (2019) A Cornucopia of Shigella Phages from the Cornhusker State. Virology 538: 45-52. [PDF]
  15. Newcomer RL, Schrad, JR, Gilcrease EB, Casjens SR, Feig M, Teschke CM, Alexandrescu AT, Parent KN. (2019) The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy. eLife 2019;8:e45345. [PDF]
  16. Bohm K, Porwollik S, Chu Weiping, Dover JA, Gilcrease EB, Casjens SR, McClelland M, Parent, KN. (2018) Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens. Mol. Microbiol 2018 (pre-print). [PDF]
  17. Doore SM, Schrad JR, Dean WF, Dover JA, Parent KN. (2018) Shigella Phages Isolated during a Dysentery Outbreak Reveal Uncommon Structures and Broad Species Diversity. J. Virol. April 2018 Volume 92 Issue 8 e02117-17. [PDF]
  18. Parent KN, Schrad JR, Cingolani G. (2018) Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy. Viruses 2018, 10(2), 67. [PDF]
  19. Schrad JR, Young EJ, Abrahao JS, Cortines JR, Parent KN. (2017) Microscopic Characterization of the Brazilian Giant Samba Virus. Viruses 2017, 9(2), 30. [PDF]
  20. Dover JA, Burmeister AR, Molineux IJ, and Parent KN. (2016) Evolved Populations of Shigella flexneri Phage Sf6 Acquire Large Deletions, Altered Genomic Architecture, and Faster Life Cycles. Genome Biol. Evol. 8(9):2827–2840. [PDF]
  21. Jin Y, Sdao SM, Dover JA, Porcek NB, Knobler CM, Gelbart WM, Parent KN. (2015) Bacteriophage P22 ejects all of its internal proteins before its genome. Virology 485:128-134. [PDF]
  22. Cho S, Dong S, Parent KN, Chen M. (2015) Immune-tolerant elastin polypeptides (iTEPs) and their application as CTL vaccine carriers. J. Drug Target. Early Online. [PDF]
  23. Porcek NB, Parent KN. (2015) Key Residues of S. flexneri OmpA Mediate Infection by Bacteriophage Sf6. J Mol Biol 427:1964-1976. [PDF]
  24. Janssen MEW, Takagi Y, Parent KN, Cardone G, Nibert ML, Baker TS. (2015) Three-Dimensional Structure of a Protozoal Double-Stranded RNA Virus That Infects the Enteric Pathogen Giardia lamblia. Journal of Virology 89(2):1182-1194. [PDF]
  25. Parent KN, Tang J, Cardone G, Gilcrease EB, Janssen ME, Olson NH, Casjens SR, Baker TS. (2014) Three-dimensional reconstructions of the bacteriophage CUS-3 virion reveal a conserved coat protein I-domain but a distinct tailspike receptor-binding domain. Virology 464-465:55-66. [PDF]
  26. Pasco V, Shi H, Xagoraraki I, Hashsham SA, Parent KN, Bruening, ML, Tarabara VV. (2014) Polyelectrolyte multilayers as anti-adhesive membrane coatings for virus concentration and recovery. Journal of Membrane Science 469:140-150.
  27. Parent KN, Erb ML, Cardone G, Nguyen K, Gilcrease EB, Porcek NB, Pogliano J, Baker TS, Casjens SR. (2014) OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella. Mol Microbiol 92(1):47-60. [PDF]
  28. Parent KN, Deedas CT, Egelman EH, Casjens SR, Baker TS, Teschke CM. (2012) Stepwise molecular display utilizing icosahedral and helical complexes of phage coat and decoration proteins in the development of robust nanoscale display vehicles. Biomaterials 33:5628-5637. [PDF]
  29. Parent KN, Gilcrease EB, Casjens SR, Baker TS. (2012) Structural evolution of the P22-like phages: Comparison of Sf6 and P22 procapsid and virion architectures. Virology 427(2):177-88. (Work featured on journal cover.) [PDF]
  30. Brodin JD, Ambroggio XI, Tang C, Parent KN, Baker TS, Tezcan FA. (2012) Metal-directed, chemically-tunable assembly of one-, two- and three-dimensional crystalline protein arrays. Nat Chem 4(5):375-82. [PDF]
  31. Yan X, Parent KN, Goodman RP, Tang J, Shou J, Nibert ML, Duncan R, Baker TS. (2011) Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber. J Virol 85(15):7483-95. (Work was featured on the journal cover.) [PDF]
  32. Ng R, Govindasamy L, Gurda BL, McKenna R, Kozyreva O, Samulski R, Parent KN, Baker TS, Agbandje-McKenna M. (2010) Structural characterization of the dual glycan binding adeno-associated virus serotype 6. J Virol 84(24):12945-12957. [PDF]
  33. Parent KN, Sinkovits RS, Suhanovsky MM, Teschke CM, Egelman EH, and Baker TS. (2010) Cryo-reconstructions of P22 polyheads suggest that scaffolding protein directs trimeric subunit interactions during phage assembly. Phys Biol 7(4) 045004:1-14. (Work featured on journal cover and in the journal's Highlights.) [PDF]
  34. Suhanovsky MM, Parent KN, Dunn SE, Baker TS., and Teschke CM. (2010) Determinants of bacteriophage P22 polyhead formation: the role of coat protein flexibility in conformational switching. Mol Micro 77(6):1568-1582. [PDF]
  35. Gurda BL¹, Parent KN ¹, Bladek H, Sinkovits RS, Dimattia MA, Rence C, Castro A, McKenna R, Olson N, Brown K, Baker TS, Agbandje-McKenna M. (2010) Human bocavirus capsid structure: Insights into the structural repertoire of the Parvoviridae. J Virol 84(12):5880-5889. ¹These authors contributed equally. [PDF]
  36. Teschke CM, Parent KN. (2010) 'Let the phage do the work': using the phage P22 coat protein structures as a framework to understand its folding and assembly mutants. Virology 401(2):119-130. (Work featured on journal cover.) [PDF]
  37. Parent KN, Khayat R, Long TH, Suhanovsky MM, Cortines JR, Teschke CM, Johnson JE, Baker TS. (2010) P22 coat protein structures reveal a novel mechanism for capsid maturation: Stability without auxiliary proteins or chemical crosslinks. Structure 18(3):390-401. (Work featured on journal cover.) [PDF]
  38. Parent KN ¹, Suhanovsky MM¹,Teschke CM. (2007) Polyhead formation in phage P22 pinpoints a region in coat protein required for conformational switching Mol Micro 65(5):1300-1310. ¹These authors contributed equally. [PDF]
  39. Parent KN, Teschke CM. (2007) GroEL/S substrate specificity based on unfolding propensity. Cell Stress and Chaperones 12(1):20-32. [PDF]
  40. Parent, K.N., Suhanovsky, M.M. and Teschke, C.M. (2007) Phage P22 procapsids equilibrate with free coat protein subunits. J Mol Biol 365(2):513-522. [PDF]
  41. Parent KN, Zlotnick A, Teschke CM. (2006) Quantitative analysis of multi-component spherical virus assembly: Scaffolding protein contributes to the global stability of phage P22 procapsids. J Mol Biol, 359(4):1097-1106. [PDF]
  42. Parent KN, Doyle SM, Anderson E, Teschke CM. (2005) Electrostatic interactions govern both nucleation and elongation during phage P22 procapsid assembly. Virology 340:33-45. [PDF]
  43. Parent KN, Ranaghan MJ, Teschke CM. (2004) A second site suppressor of a folding defect functions via interactions with a chaperone network to improve folding and assembly in vivo. Mol Micro, 54(4):1036-1050. [PDF]
  44. Doyle SM, Anderson E, Parent KN, Teschke CM. (2004) A concerted mechanism for the suppression of a folding defect through interactions with chaperones. J Biol Chem 279:17473-17482. [PDF]